List of GO terms enriched from the 231 up-regulated annotate genes of the 35d-49d FF constrast (DE genes with Ensembl gene annotation for rabbit) using g:profiler.
source | term_name | term_id | p_value | neg_log10_adj_p_value | term_size | query_size | intersection_size | fract_gene_func | intersection |
|---|---|---|---|---|---|---|---|---|---|
GO:BP | defense response | GO:0006952 | 0.000000000000000000000001213832 | 23.915841 | 1,396 | 184 | 69 | 0.04942693 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,LPL,CXCL11,IFI44L,CXCL9,FGB,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100,CCN3,NFKBIZ,CD96,BIRC3,TLR3,MUC13,ERAP1,IRF1,DTX3L,IFIH1,OAS3,CLEC1B,OAS2,XCR1,TNFRSF1A,DNASE1L3,SLAMF7,NMI,PSME2,B2M,TRIM14,NUB1,OPTN,IFNG,CD200R1,TRIM40,IL18,PSME1,ABCD2 |
GO:BP | response to other organism | GO:0051707 | 0.000000000000000000000186666370 | 21.728934 | 1,166 | 70 | 38 | 0.03259005 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,IFI44L,CXCL9,FGB,PSMB8,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100 |
GO:BP | response to external biotic stimulus | GO:0043207 | 0.000000000000000000000186666370 | 21.728934 | 1,166 | 70 | 38 | 0.03259005 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,IFI44L,CXCL9,FGB,PSMB8,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100 |
GO:BP | response to biotic stimulus | GO:0009607 | 0.000000000000000000000427645980 | 21.368916 | 1,193 | 70 | 38 | 0.03185247 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,IFI44L,CXCL9,FGB,PSMB8,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100 |
GO:BP | defense response to other organism | GO:0098542 | 0.000000000000000000003848794546 | 20.414675 | 920 | 70 | 34 | 0.03695652 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,DDX58,IFIT3,ENSG00000213512,MX1,OASL,AQP4,IFI44L,FGB,PSMB8,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100 |
GO:BP | response to external stimulus | GO:0009605 | 0.000000000000000000623890415803 | 18.204892 | 2,151 | 166 | 72 | 0.03347280 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,LPL,CXCL11,IFI44L,CXCL9,FGB,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100,CCN3,NFKBIZ,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,ERAP1,DPP4,FAP,EFNA1,IRF1,DTX3L,CXCR6,IFIH1,OAS3,OAS2,XCR1,TNFRSF1A,DNASE1L3,SLAMF7,AOC1,ITGA4,PSME2,B2M,TRIM14,FBXL3,NUB1,OPTN,IFNG,CD200R1 |
GO:BP | immune response | GO:0006955 | 0.000000000000000001399809740181 | 17.853931 | 1,885 | 166 | 67 | 0.03554377 | REG3G,UBD,USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,IFI44L,CXCL9,FGB,PSMB8,PSMB9,ENSG00000181374,PARP14,ALDOC,PARP9,DHX58,IL15,IGHM,IFI35,ENSG00000154451,STAT1,CCL4,CTSS,PRF1,SP100,PIGR,NFKBIZ,CD96,IL18R1,BIRC3,TLR3,MUC13,ERAP1,IL18BP,IRF1,ENSG00000243290,CXCR6,IFIH1,OAS3,TNFSF13,OAS2,XCR1,DNASE1L3,STOM,SLCO4C1,SLAMF7,IL17B,AOC1,ITGA4,PSME2,B2M,TRIM14,NUB1,IFNG,CD200R1 |
GO:BP | biological process involved in interspecies interaction between organisms | GO:0044419 | 0.000000000000000003660986043180 | 17.436402 | 1,537 | 70 | 38 | 0.02472349 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,IFI44L,CXCL9,FGB,PSMB8,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100 |
GO:BP | response to cytokine | GO:0034097 | 0.000000000000000016785911579506 | 16.775055 | 966 | 129 | 42 | 0.04347826 | UBD,USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,CXCL9,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,ENSG00000154451,STAT1,CCL4,SP100,TNFRSF17,IL18R1,BIRC3,EIF2AK2,IL18BP,FASLG,IRF1,IFIH1,DCSTAMP,OAS3,TNFSF13,OAS2,TNFRSF1A |
GO:BP | immune system process | GO:0002376 | 0.000000000000000140226446915863 | 15.853170 | 2,657 | 144 | 70 | 0.02634550 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,IFI44L,CXCL9,FGB,TAP1,PSMB8,PSMB9,ENSG00000181374,PARP14,ALDOC,PARP9,DHX58,IL15,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,CTSS,PRF1,SP100,CCN3,PIGR,NFKBIZ,CD96,IL18R1,BIRC3,TLR3,EIF2AK2,MUC13,ERAP1,DPP4,IL18BP,IRF1,DTX3L,ENSG00000243290,CXCR6,IFIH1,DCSTAMP,OAS3,TNFSF13,OAS2,XCR1,DNASE1L3,STOM,SLCO4C1,SLAMF7,IL17B,AOC1,ITGA4 |
GO:BP | response to virus | GO:0009615 | 0.000000000000000148770848762731 | 15.827482 | 280 | 127 | 25 | 0.08928571 | DDX60,HERC5,CCL5,ISG15,IRF7,IFI44,DDX58,IFIT3,MX1,OASL,IFI44L,PARP9,DHX58,IFIT5,STAT1,CCL4,PRF1,BIRC3,TLR3,EIF2AK2,IRF1,DTX3L,IFIH1,OAS3,OAS2 |
GO:BP | innate immune response | GO:0045087 | 0.000000000000000606802940486364 | 15.216952 | 733 | 163 | 40 | 0.05457026 | UBD,USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,DDX58,IFIT3,ENSG00000213512,MX1,OASL,AQP4,PSMB8,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IGHM,IFI35,ENSG00000154451,STAT1,CCL4,SP100,BIRC3,TLR3,MUC13,ERAP1,IRF1,IFIH1,OAS3,OAS2,SLAMF7,PSME2,B2M,TRIM14,NUB1,IFNG |
GO:BP | defense response to virus | GO:0051607 | 0.000000000000000930958413945217 | 15.031070 | 183 | 127 | 21 | 0.11475410 | DDX60,HERC5,ISG15,IRF7,DDX58,IFIT3,MX1,OASL,IFI44L,PARP9,DHX58,IFIT5,STAT1,PRF1,BIRC3,TLR3,IRF1,DTX3L,IFIH1,OAS3,OAS2 |
GO:BP | defense response to symbiont | GO:0140546 | 0.000000000000000930958413945217 | 15.031070 | 183 | 127 | 21 | 0.11475410 | DDX60,HERC5,ISG15,IRF7,DDX58,IFIT3,MX1,OASL,IFI44L,PARP9,DHX58,IFIT5,STAT1,PRF1,BIRC3,TLR3,IRF1,DTX3L,IFIH1,OAS3,OAS2 |
GO:BP | cellular response to cytokine stimulus | GO:0071345 | 0.000000000000005368397450493169 | 14.270155 | 901 | 129 | 38 | 0.04217536 | USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,CXCL11,CXCL9,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,ENSG00000154451,STAT1,CCL4,SP100,TNFRSF17,IL18R1,BIRC3,IL18BP,FASLG,IRF1,DCSTAMP,OAS3,TNFSF13,OAS2,TNFRSF1A |
GO:BP | cytokine-mediated signaling pathway | GO:0019221 | 0.000000000000061736749842383296 | 13.209456 | 753 | 129 | 34 | 0.04515272 | USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,CXCL10,IFIT3,MX1,OASL,CXCL11,CXCL9,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,STAT1,CCL4,SP100,TNFRSF17,IL18R1,BIRC3,IL18BP,FASLG,IRF1,OAS3,TNFSF13,OAS2,TNFRSF1A |
GO:BP | response to interferon-gamma | GO:0034341 | 0.000000000000115904040239146978 | 12.935901 | 156 | 163 | 20 | 0.12820513 | UBD,GBP1,CCL5,IRF7,ENSG00000213512,OASL,AQP4,ENSG00000181374,PARP14,PARP9,ENSG00000154451,STAT1,CCL4,SP100,IRF1,OAS3,OAS2,B2M,NUB1,IFNG |
GO:BP | response to stress | GO:0006950 | 0.000000000000474886465046837899 | 12.323410 | 3,397 | 108 | 61 | 0.01795702 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CCL5,ISG15,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,UBA7,AQP4,LPL,CXCL11,IFI44L,CXCL9,FGB,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,UBE2L6,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,PRF1,SP100,ECRG4,FGF12,EGLN3,CCN3,NFKBIZ,MAP2K6,CD96,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,PARP16,ERAP1,DPP4,FAP,IRF1,USP25,DTX3L |
GO:BP | cellular response to interferon-gamma | GO:0071346 | 0.000000000003282654233649404349 | 11.483775 | 138 | 163 | 18 | 0.13043478 | GBP1,CCL5,IRF7,ENSG00000213512,OASL,AQP4,ENSG00000181374,PARP14,PARP9,ENSG00000154451,STAT1,CCL4,SP100,IRF1,OAS3,OAS2,B2M,IFNG |
GO:BP | cellular response to type I interferon | GO:0071357 | 0.000000000012301190281340669147 | 10.910053 | 90 | 127 | 14 | 0.15555556 | USP18,XAF1,ISG15,IRF7,IFIT3,MX1,OASL,PSMB8,IFI35,STAT1,SP100,IRF1,OAS3,OAS2 |
GO:BP | type I interferon signaling pathway | GO:0060337 | 0.000000000012301190281340669147 | 10.910053 | 90 | 127 | 14 | 0.15555556 | USP18,XAF1,ISG15,IRF7,IFIT3,MX1,OASL,PSMB8,IFI35,STAT1,SP100,IRF1,OAS3,OAS2 |
GO:BP | response to type I interferon | GO:0034340 | 0.000000000023115354598141865051 | 10.636099 | 94 | 127 | 14 | 0.14893617 | USP18,XAF1,ISG15,IRF7,IFIT3,MX1,OASL,PSMB8,IFI35,STAT1,SP100,IRF1,OAS3,OAS2 |
GO:BP | regulation of response to external stimulus | GO:0032101 | 0.000000001995067425084725033172 | 8.700042 | 868 | 108 | 28 | 0.03225806 | DDX60,USP18,HERC5,CCL5,DDX58,CXCL10,LPL,FGB,PSMB8,CASP4,PSMB9,PARP14,PARP9,DHX58,IL15,ENSG00000154451,STAT1,CCL4,CCN3,NFKBIZ,BIRC3,TLR3,MUC13,ERAP1,DPP4,FAP,IRF1,DTX3L |
GO:BP | regulation of defense response | GO:0031347 | 0.000000002804619078667083451745 | 8.552126 | 581 | 182 | 30 | 0.05163511 | USP18,HERC5,CCL5,DDX58,LPL,PSMB8,CASP4,PSMB9,PARP14,PARP9,DHX58,IL15,ENSG00000154451,STAT1,CCN3,NFKBIZ,BIRC3,TLR3,MUC13,ERAP1,IRF1,DTX3L,TNFRSF1A,DNASE1L3,PSME2,OPTN,IFNG,CD200R1,IL18,PSME1 |
GO:BP | response to organic substance | GO:0010033 | 0.000000024886493558213578860833 | 7.604036 | 2,532 | 163 | 60 | 0.02369668 | REG3G,UBD,USP18,GBP1,ENSG00000211892,XAF1,CYP1A1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,LPL,CXCL11,CXCL9,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,ENSG00000154451,STAT1,CCL4,CTSS,SP100,TNFRSF17,IL18R1,BIRC3,TLR3,EIF2AK2,PARP16,IL18BP,FASLG,IRF1,USP25,IFIH1,DCSTAMP,OAS3,TNFSF13,OAS2,TNFRSF1A,ENSG00000198848,AOC1,ITGA4,PSME2,SLC26A3,B2M,UBB,NUB1,OPTN,IFNG |
GO:BP | immune effector process | GO:0002252 | 0.000000048322508023502931551879 | 7.315851 | 1,137 | 143 | 35 | 0.03078276 | DDX60,HERC5,ENSG00000211892,ISG15,IRF7,DDX58,IFIT3,MX1,OASL,IFI44L,ALDOC,PARP9,DHX58,IGHM,IFIT5,STAT1,CTSS,PRF1,PIGR,NFKBIZ,IL18R1,BIRC3,TLR3,IRF1,DTX3L,ENSG00000243290,IFIH1,OAS3,TNFSF13,OAS2,DNASE1L3,STOM,SLCO4C1,SLAMF7,AOC1 |
GO:BP | cellular response to organic substance | GO:0071310 | 0.000000058327958535413050827727 | 7.234123 | 2,181 | 70 | 32 | 0.01467217 | USP18,GBP1,ENSG00000211892,XAF1,CYP1A1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,LPL,CXCL11,CXCL9,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,ENSG00000154451,STAT1,CCL4,CTSS,SP100 |
GO:BP | interferon-gamma-mediated signaling pathway | GO:0060333 | 0.000000063460611122006301493617 | 7.197496 | 84 | 163 | 12 | 0.14285714 | GBP1,IRF7,OASL,PARP14,PARP9,STAT1,SP100,IRF1,OAS3,OAS2,B2M,IFNG |
GO:BP | response to chemical | GO:0042221 | 0.000000152206983284344353531820 | 6.817565 | 3,373 | 129 | 59 | 0.01749185 | REG3G,UBD,USP18,GBP1,ENSG00000211892,XAF1,CYP1A1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,LPL,CXCL11,CXCL9,FGB,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,ENSG00000154451,STAT1,CCL4,CTSS,SP100,EGLN3,CCN3,PIGR,TNFRSF17,IL18R1,BIRC3,TLR3,EIF2AK2,PARP16,DPP4,IL18BP,EFNA1,FASLG,IRF1,USP25,CXCR6,SLC5A1,IFIH1,DCSTAMP,OAS3,TNFSF13,OAS2,XCR1,TNFRSF1A |
GO:BP | regulation of immune system process | GO:0002682 | 0.000000193592664340971528612323 | 6.713111 | 1,378 | 211 | 48 | 0.03483309 | DDX60,USP18,HERC5,GBP1,ENSG00000211892,CCL5,IRF7,DDX58,CXCL10,PSMB8,PSMB9,PARP14,PARP9,DHX58,IL15,IGHM,ENSG00000154451,STAT1,CCL4,CCN3,PIGR,NFKBIZ,CD96,IL18R1,BIRC3,TLR3,MUC13,ERAP1,DPP4,IRF1,DTX3L,ENSG00000243290,DCSTAMP,TNFSF13,DNASE1L3,SLAMF7,ITGA4,PSME2,B2M,IFNG,CD200R1,IL18,PSME1,TAPBPL,FCER1A,JAML,ITGB7,PTPN22 |
GO:BP | regulation of response to biotic stimulus | GO:0002831 | 0.000000338874124237492044741868 | 6.469962 | 361 | 108 | 17 | 0.04709141 | DDX60,USP18,HERC5,CCL5,DDX58,PSMB8,PSMB9,PARP14,PARP9,DHX58,ENSG00000154451,STAT1,BIRC3,MUC13,ERAP1,IRF1,DTX3L |
GO:BP | negative regulation of viral process | GO:0048525 | 0.000001214058897999351946611971 | 5.915760 | 113 | 155 | 12 | 0.10619469 | CCL5,ISG15,MX1,OASL,IFIT5,STAT1,CCL4,SP100,EIF2AK2,OAS3,OAS2,TRIM14 |
GO:BP | regulation of immune response | GO:0050776 | 0.000001311264342626255587705326 | 5.882310 | 891 | 211 | 36 | 0.04040404 | USP18,GBP1,ENSG00000211892,CCL5,IRF7,PSMB8,PSMB9,PARP14,PARP9,DHX58,IL15,IGHM,ENSG00000154451,STAT1,PIGR,NFKBIZ,CD96,IL18R1,BIRC3,MUC13,ERAP1,IRF1,ENSG00000243290,TNFSF13,SLAMF7,ITGA4,PSME2,B2M,IFNG,CD200R1,IL18,PSME1,FCER1A,JAML,ITGB7,PTPN22 |
GO:BP | regulation of type I interferon production | GO:0032479 | 0.000001550584659613657971142728 | 5.809505 | 119 | 118 | 11 | 0.09243697 | HERC5,ISG15,IRF7,DDX58,UBA7,DHX58,UBE2L6,STAT1,TLR3,IRF1,IFIH1 |
GO:BP | cellular response to chemical stimulus | GO:0070887 | 0.000001584516291555918042184906 | 5.800103 | 2,725 | 163 | 59 | 0.02165138 | USP18,GBP1,ENSG00000211892,XAF1,CYP1A1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,AQP4,LPL,CXCL11,CXCL9,PSMB8,CASP4,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IFI35,ENSG00000154451,STAT1,CCL4,CTSS,SP100,EGLN3,CCN3,TNFRSF17,IL18R1,BIRC3,PARP16,DPP4,IL18BP,FASLG,IRF1,CXCR6,IFIH1,DCSTAMP,OAS3,TNFSF13,OAS2,XCR1,TNFRSF1A,ENSG00000198848,AOC1,ITGA4,PSME2,SLC26A3,B2M,UBB,OPTN,IFNG |
GO:BP | type I interferon production | GO:0032606 | 0.000001696887797764303555930060 | 5.770347 | 120 | 118 | 11 | 0.09166667 | HERC5,ISG15,IRF7,DDX58,UBA7,DHX58,UBE2L6,STAT1,TLR3,IRF1,IFIH1 |
GO:BP | response to tumor necrosis factor | GO:0034612 | 0.000001724227102959162319416667 | 5.763406 | 269 | 159 | 17 | 0.06319703 | UBD,GBP1,CCL5,PSMB8,CASP4,PSMB9,ENSG00000181374,STAT1,CCL4,TNFRSF17,BIRC3,FASLG,DCSTAMP,TNFSF13,TNFRSF1A,PSME2,NUB1 |
GO:BP | ISG15-protein conjugation | GO:0032020 | 0.000002167253546770325888046888 | 5.664090 | 6 | 51 | 4 | 0.66666667 | HERC5,ISG15,UBA7,UBE2L6 |
GO:BP | negative regulation of type I interferon production | GO:0032480 | 0.000007462570900447075241540551 | 5.127112 | 44 | 51 | 6 | 0.13636364 | HERC5,ISG15,DDX58,UBA7,DHX58,UBE2L6 |
GO:BP | regulation of response to stress | GO:0080134 | 0.000012889965823233560490886085 | 4.889748 | 1,245 | 182 | 38 | 0.03052209 | REG3G,USP18,HERC5,CCL5,DDX58,LPL,FGB,PSMB8,CASP4,PSMB9,PARP14,PARP9,DHX58,IL15,ENSG00000154451,STAT1,CCN3,NFKBIZ,BIRC3,TLR3,EIF2AK2,MUC13,ERAP1,FAP,IRF1,USP25,DTX3L,TNFRSF1A,DNASE1L3,CRYAB,PSME2,B2M,OPTN,IFNG,CD200R1,UNC5CL,IL18,PSME1 |
GO:BP | cellular response to tumor necrosis factor | GO:0071356 | 0.000017482683293040651424741366 | 4.757392 | 250 | 151 | 15 | 0.06000000 | GBP1,CCL5,PSMB8,CASP4,PSMB9,ENSG00000181374,STAT1,CCL4,TNFRSF17,BIRC3,FASLG,DCSTAMP,TNFSF13,TNFRSF1A,PSME2 |
GO:BP | cell surface receptor signaling pathway | GO:0007166 | 0.000024195064912376361729133556 | 4.616273 | 2,738 | 129 | 48 | 0.01753104 | USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,IRF7,CXCL10,IFIT3,MX1,OASL,CXCL11,CXCL9,FGB,ANGPTL3,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,IL15,IGHM,IFI35,STAT1,CCL4,SP100,CCN3,PIGR,NFKBIZ,TNFRSF17,IL18R1,BIRC3,TLR3,MUC13,IL18BP,EFNA1,FASLG,IRF1,DTX3L,ENSG00000243290,DELE1,OAS3,CLEC1B,TNFSF13,OAS2,TNFRSF1A |
GO:BP | inflammatory response | GO:0006954 | 0.000029148197714575058126472429 | 4.535388 | 560 | 184 | 24 | 0.04285714 | USP18,CCL5,CXCL10,LPL,CXCL11,CXCL9,CASP4,ENSG00000181374,IL15,ENSG00000154451,CCL4,CCN3,NFKBIZ,CD96,BIRC3,TLR3,XCR1,TNFRSF1A,DNASE1L3,NMI,IFNG,CD200R1,IL18,ABCD2 |
GO:BP | pattern recognition receptor signaling pathway | GO:0002221 | 0.000030604999020683399193771407 | 4.514208 | 197 | 118 | 12 | 0.06091371 | REG3G,DDX60,IRF7,DDX58,FGB,DHX58,CTSS,MAP2K6,BIRC3,TLR3,IRF1,IFIH1 |
GO:BP | regulation of innate immune response | GO:0045088 | 0.000045421678704520188169999062 | 4.342737 | 277 | 106 | 13 | 0.04693141 | USP18,CCL5,PSMB8,PSMB9,PARP14,PARP9,DHX58,ENSG00000154451,STAT1,BIRC3,MUC13,ERAP1,IRF1 |
GO:BP | negative regulation of viral genome replication | GO:0045071 | 0.000054763715872064485106103515 | 4.261507 | 64 | 127 | 8 | 0.12500000 | CCL5,ISG15,MX1,OASL,IFIT5,EIF2AK2,OAS3,OAS2 |
GO:BP | response to stimulus | GO:0050896 | 0.000062109448621125136827392232 | 4.206842 | 7,650 | 168 | 113 | 0.01477124 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,LYG2,XAF1,CYP1A1,CCL5,ISG15,ACTN2,IRF7,IFI44,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,UBA7,AQP4,LPL,CXCL11,IFI44L,CXCL9,FGB,ANGPTL3,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,ALDOC,PARP9,DHX58,IL15,UBE2L6,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,CTSS,PRF1,SP100,ECRG4,FGF12,EGLN3,CCN3,PIGR,NFKBIZ,TNFRSF17,MAP2K6,CD96,IL18R1,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,PARP16,ERAP1,DPP4,FAP,IL18BP,EFNA1,FASLG,IRF1,USP25,DTX3L,ENSG00000243290,CXCR6,SLC5A1,IFIH1,DCSTAMP,DELE1,PCP4,OAS3,CLEC1B,TNFSF13,OAS2,XCR1,TNFRSF1A,DNASE1L3,STOM,SLCO4C1,CRYAB,SLAMF7,ENSG00000198848,IL17B,GNRH1,AOC1,ITGA4,NAMPT,NMI,PSME2,SLC26A3,B2M,TRIM14,UBB,FBXL3,NUB1,OPTN,TP53INP1,IFNG,GLIPR2,CD200R1,PDLIM1,UBE2T |
GO:BP | response to bacterium | GO:0009617 | 0.000079564469507770904069428319 | 4.099281 | 488 | 35 | 10 | 0.02049180 | REG3G,ENSG00000211892,LYG2,CCL5,ISG15,CXCL10,ENSG00000213512,CXCL11,CXCL9,FGB |
GO:BP | positive regulation of interferon-beta production | GO:0032728 | 0.000109134576340845330867830587 | 3.962038 | 30 | 118 | 6 | 0.20000000 | IRF7,DDX58,DHX58,TLR3,IRF1,IFIH1 |
GO:BP | cytoplasmic pattern recognition receptor signaling pathway in response to virus | GO:0039528 | 0.000109134576340845330867830587 | 3.962038 | 30 | 118 | 6 | 0.20000000 | DDX60,IRF7,DDX58,DHX58,BIRC3,IFIH1 |
GO:BP | positive regulation of response to external stimulus | GO:0032103 | 0.000115799809442681332746945266 | 3.936292 | 431 | 182 | 20 | 0.04640371 | DDX60,CCL5,CXCL10,LPL,PSMB8,PSMB9,PARP9,DHX58,IL15,ENSG00000154451,CCL4,NFKBIZ,TLR3,MUC13,TNFRSF1A,PSME2,OPTN,IFNG,IL18,PSME1 |
GO:BP | cell communication | GO:0007154 | 0.000277535896523226186145827388 | 3.556681 | 5,611 | 166 | 89 | 0.01586170 | REG3G,DDX60,UBD,USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,MX1,FAM3B,OASL,LPL,CXCL11,CXCL9,FGB,ANGPTL3,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFI35,IFIT5,STAT1,TNNI3K,CCL4,CTSS,SP100,FGF12,CCN3,PIGR,NFKBIZ,TNFRSF17,MAP2K6,IL18R1,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,PARP16,ERAP1,DPP4,IL18BP,EFNA1,FASLG,IRF1,DTX3L,ENSG00000243290,CXCR6,KCNA2,IFIH1,DELE1,PCP4,OAS3,CLEC1B,TNFSF13,SNCG,OAS2,XCR1,TNFRSF1A,IL17B,GNRH1,AOC1,ITGA4,NAMPT,NMI,ZDHHC2,PSME2,B2M,TRIM14,UBB,PCSK5,OPTN,TP53INP1,IFNG,GLIPR2,CD200R1 |
GO:BP | chemokine-mediated signaling pathway | GO:0070098 | 0.000302265206565076425138799410 | 3.519612 | 65 | 63 | 6 | 0.09230769 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | cytoplasmic pattern recognition receptor signaling pathway | GO:0002753 | 0.000356210416785756873829515978 | 3.448293 | 68 | 211 | 9 | 0.13235294 | DDX60,IRF7,DDX58,DHX58,MAP2K6,BIRC3,IFIH1,UBB,PTPN22 |
GO:BP | negative regulation of multicellular organismal process | GO:0051241 | 0.000387454235211464584256318977 | 3.411780 | 897 | 106 | 21 | 0.02341137 | REG3G,HERC5,GBP1,ISG15,DDX58,CXCL10,UBA7,FGB,DHX58,IL15,UBE2L6,STAT1,SP100,CCN3,MAP2K6,IL18R1,TLR3,FAP,EFNA1,FASLG,IRF1 |
GO:BP | positive regulation of defense response | GO:0031349 | 0.000422273323294823936437797363 | 3.374406 | 301 | 182 | 16 | 0.05315615 | CCL5,LPL,PSMB8,PSMB9,PARP9,IL15,ENSG00000154451,NFKBIZ,TLR3,MUC13,TNFRSF1A,PSME2,OPTN,IFNG,IL18,PSME1 |
GO:BP | antimicrobial humoral response | GO:0019730 | 0.000431778054205419028251794478 | 3.364739 | 138 | 52 | 7 | 0.05072464 | REG3G,CXCL10,CXCL11,CXCL9,FGB,ENSG00000181374,IGHM |
GO:BP | positive regulation of response to stimulus | GO:0048584 | 0.000464440964597444987983776432 | 3.333069 | 2,057 | 86 | 29 | 0.01409820 | REG3G,DDX60,UBD,GBP1,ENSG00000211892,CCL5,DDX58,CXCL10,LPL,FGB,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFIT5,ENSG00000154451,CCL4,CCN3,NFKBIZ,MAP2K6,IL18R1,BIRC3,TLR3 |
GO:BP | signaling | GO:0023052 | 0.000547859505981796216476931161 | 3.261331 | 5,614 | 129 | 72 | 0.01282508 | REG3G,DDX60,UBD,USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,MX1,FAM3B,OASL,LPL,CXCL11,CXCL9,FGB,ANGPTL3,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFI35,IFIT5,STAT1,TNNI3K,CCL4,CTSS,SP100,FGF12,CCN3,PIGR,NFKBIZ,TNFRSF17,MAP2K6,IL18R1,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,PARP16,ERAP1,DPP4,IL18BP,EFNA1,FASLG,IRF1,DTX3L,ENSG00000243290,CXCR6,KCNA2,IFIH1,DELE1,PCP4,OAS3,CLEC1B,TNFSF13,SNCG,OAS2,XCR1,TNFRSF1A |
GO:BP | positive regulation of interferon-alpha production | GO:0032727 | 0.000572500823678786185076672322 | 3.242224 | 21 | 118 | 5 | 0.23809524 | IRF7,DDX58,STAT1,TLR3,IFIH1 |
GO:BP | response to chemokine | GO:1990868 | 0.000608331839702419400507660274 | 3.215859 | 73 | 63 | 6 | 0.08219178 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | cellular response to chemokine | GO:1990869 | 0.000608331839702419400507660274 | 3.215859 | 73 | 63 | 6 | 0.08219178 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | viral genome replication | GO:0019079 | 0.000807240741663370125688614642 | 3.092997 | 123 | 127 | 9 | 0.07317073 | CCL5,ISG15,MX1,OASL,IFIT5,EIF2AK2,CXCR6,OAS3,OAS2 |
GO:BP | cellular response to stimulus | GO:0051716 | 0.000829106433493037174760342811 | 3.081390 | 6,390 | 129 | 78 | 0.01220657 | REG3G,DDX60,UBD,USP18,GBP1,ENSG00000211892,XAF1,CYP1A1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,ENSG00000213512,MX1,OASL,UBA7,AQP4,LPL,CXCL11,CXCL9,FGB,ANGPTL3,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,UBE2L6,IGHM,IFI35,IFIT5,ENSG00000154451,STAT1,CCL4,CTSS,SP100,ECRG4,FGF12,EGLN3,CCN3,PIGR,NFKBIZ,TNFRSF17,MAP2K6,IL18R1,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,PARP16,ERAP1,DPP4,IL18BP,EFNA1,FASLG,IRF1,USP25,DTX3L,ENSG00000243290,CXCR6,IFIH1,DCSTAMP,DELE1,PCP4,OAS3,CLEC1B,TNFSF13,OAS2,XCR1,TNFRSF1A |
GO:BP | MDA-5 signaling pathway | GO:0039530 | 0.000905343589680389880525179791 | 3.043187 | 10 | 118 | 4 | 0.40000000 | DDX60,IRF7,DHX58,IFIH1 |
GO:BP | pyridine-containing compound metabolic process | GO:0072524 | 0.000981256233074647918335209340 | 3.008218 | 35 | 145 | 6 | 0.17142857 | IDO1,PARP9,IDO2,PARP16,AOX1,NAMPT |
GO:BP | regulation of interferon-beta production | GO:0032648 | 0.001038719220941788532949767720 | 2.983502 | 43 | 118 | 6 | 0.13953488 | IRF7,DDX58,DHX58,TLR3,IRF1,IFIH1 |
GO:BP | positive regulation of type I interferon production | GO:0032481 | 0.001309906831292643016387278188 | 2.882760 | 71 | 118 | 7 | 0.09859155 | IRF7,DDX58,DHX58,STAT1,TLR3,IRF1,IFIH1 |
GO:BP | interferon-beta production | GO:0032608 | 0.001371682004789217352788699422 | 2.862747 | 45 | 118 | 6 | 0.13333333 | IRF7,DDX58,DHX58,TLR3,IRF1,IFIH1 |
GO:BP | regulation of defense response to virus | GO:0050688 | 0.001543310162995970881427698629 | 2.811547 | 57 | 221 | 8 | 0.14035088 | HERC5,DDX58,PARP9,DHX58,STAT1,DTX3L,PTPN22,ELMOD2 |
GO:BP | regulation of viral genome replication | GO:0045069 | 0.001564854971833291863436699032 | 2.805526 | 98 | 127 | 8 | 0.08163265 | CCL5,ISG15,MX1,OASL,IFIT5,EIF2AK2,OAS3,OAS2 |
GO:BP | interferon-alpha production | GO:0032607 | 0.001798488588862949067240237788 | 2.745092 | 26 | 118 | 5 | 0.19230769 | IRF7,DDX58,STAT1,TLR3,IFIH1 |
GO:BP | regulation of interferon-alpha production | GO:0032647 | 0.001798488588862949067240237788 | 2.745092 | 26 | 118 | 5 | 0.19230769 | IRF7,DDX58,STAT1,TLR3,IFIH1 |
GO:BP | signal transduction | GO:0007165 | 0.001812087697498577327712143692 | 2.741821 | 5,187 | 129 | 67 | 0.01291691 | REG3G,DDX60,UBD,USP18,GBP1,ENSG00000211892,XAF1,CCL5,ISG15,ACTN2,IRF7,DDX58,CXCL10,IFIT3,MX1,OASL,LPL,CXCL11,CXCL9,FGB,ANGPTL3,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFI35,IFIT5,STAT1,CCL4,CTSS,SP100,FGF12,CCN3,PIGR,NFKBIZ,TNFRSF17,MAP2K6,IL18R1,BIRC3,TLR3,NUAK2,EIF2AK2,MUC13,PARP16,ERAP1,IL18BP,EFNA1,FASLG,IRF1,DTX3L,ENSG00000243290,CXCR6,IFIH1,DELE1,PCP4,OAS3,CLEC1B,TNFSF13,OAS2,XCR1,TNFRSF1A |
GO:BP | regulation of viral process | GO:0050792 | 0.001910238516671241464431330037 | 2.718912 | 220 | 127 | 11 | 0.05000000 | CCL5,ISG15,MX1,OASL,IFIT5,STAT1,CCL4,SP100,EIF2AK2,OAS3,OAS2 |
GO:BP | neutrophil chemotaxis | GO:0030593 | 0.002115513015804404515357584060 | 2.674584 | 90 | 63 | 6 | 0.06666667 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | cell death | GO:0008219 | 0.002164590581544949873110672556 | 2.664624 | 1,743 | 166 | 39 | 0.02237522 | IDO1,UBD,GZMH,CCL5,ACTN2,IRF7,CXCL10,IFIT3,MX1,FGB,CASP4,TNFSF10,STAT1,RETREG1,PRF1,SP100,EGLN3,CCN3,AGR3,BIRC3,TLR3,KRT12,NUAK2,PARP16,FAP,FASLG,IRF1,DELE1,SNCG,TNFRSF1A,DNASE1L3,LIPK,CRYAB,ITGA4,UBB,OPTN,TP53INP1,IFNG,CD200R1 |
GO:BP | regulation of biological process involved in symbiotic interaction | GO:0043903 | 0.002952296230442423476819646666 | 2.529840 | 230 | 127 | 11 | 0.04782609 | CCL5,ISG15,MX1,OASL,IFIT5,STAT1,CCL4,SP100,EIF2AK2,OAS3,OAS2 |
GO:BP | regulation of response to stimulus | GO:0048583 | 0.003052600725649531714089857104 | 2.515330 | 3,708 | 110 | 47 | 0.01267530 | REG3G,DDX60,UBD,USP18,HERC5,GBP1,ENSG00000211892,CCL5,ACTN2,IRF7,DDX58,CXCL10,LPL,FGB,PSMB8,CASP4,TNFSF10,PSMB9,ENSG00000181374,PARP14,PARP9,DHX58,IL15,IGHM,IFIT5,ENSG00000154451,STAT1,CCL4,SP100,CCN3,PIGR,NFKBIZ,MAP2K6,CD96,IL18R1,BIRC3,TLR3,EIF2AK2,MUC13,ERAP1,DPP4,FAP,FASLG,IRF1,USP25,DTX3L,ENSG00000243290 |
GO:BP | antimicrobial humoral immune response mediated by antimicrobial peptide | GO:0061844 | 0.003677024164072379038004090290 | 2.434504 | 77 | 45 | 5 | 0.06493506 | REG3G,CXCL10,CXCL11,CXCL9,ENSG00000181374 |
GO:BP | regulation of immune effector process | GO:0002697 | 0.003914145159183410327408125795 | 2.407363 | 365 | 221 | 18 | 0.04931507 | DDX60,HERC5,ENSG00000211892,DDX58,PARP9,DHX58,STAT1,NFKBIZ,IL18R1,DTX3L,ENSG00000243290,TNFSF13,DNASE1L3,B2M,IFNG,IL18,PTPN22,ELMOD2 |
GO:BP | NAD biosynthetic process | GO:0009435 | 0.004047458370312012262970391419 | 2.392818 | 25 | 145 | 5 | 0.20000000 | IDO1,PARP9,IDO2,PARP16,NAMPT |
GO:BP | tumor necrosis factor-mediated signaling pathway | GO:0033209 | 0.004197456123848869111170323265 | 2.377014 | 166 | 182 | 11 | 0.06626506 | PSMB8,CASP4,PSMB9,STAT1,TNFRSF17,BIRC3,FASLG,TNFSF13,TNFRSF1A,PSME2,PSME1 |
GO:BP | neutrophil migration | GO:1990266 | 0.004945996229477905674343229947 | 2.305746 | 104 | 63 | 6 | 0.05769231 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | pyridine nucleotide biosynthetic process | GO:0019363 | 0.004975769353623906744721328010 | 2.303140 | 26 | 145 | 5 | 0.19230769 | IDO1,PARP9,IDO2,PARP16,NAMPT |
GO:BP | nicotinamide nucleotide biosynthetic process | GO:0019359 | 0.004975769353623906744721328010 | 2.303140 | 26 | 145 | 5 | 0.19230769 | IDO1,PARP9,IDO2,PARP16,NAMPT |
GO:BP | lymphocyte chemotaxis | GO:0048247 | 0.005756645269954705629311675352 | 2.239831 | 60 | 63 | 5 | 0.08333333 | CCL5,CXCL10,CXCL11,ENSG00000181374,CCL4 |
GO:BP | granulocyte chemotaxis | GO:0071621 | 0.007228773319225538333820946235 | 2.140935 | 111 | 63 | 6 | 0.05405405 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | viral process | GO:0016032 | 0.007302263468120255042459465500 | 2.136543 | 487 | 157 | 17 | 0.03490760 | CCL5,ISG15,IRF7,MX1,OASL,IFIT5,STAT1,CCL4,SP100,EIF2AK2,CXCR6,OAS3,OAS2,B2M,TRIM14,UBB,PCSK5 |
GO:BP | regulation of inflammatory response | GO:0050727 | 0.007712192874356452350348423153 | 2.112822 | 292 | 181 | 14 | 0.04794521 | USP18,CCL5,LPL,CASP4,IL15,CCN3,NFKBIZ,BIRC3,TLR3,TNFRSF1A,DNASE1L3,IFNG,CD200R1,IL18 |
GO:BP | cellular response to virus | GO:0098586 | 0.007725832957862535134430093109 | 2.112055 | 60 | 118 | 6 | 0.10000000 | DDX60,IRF7,DDX58,DHX58,BIRC3,IFIH1 |
GO:BP | regulation of cytokine production | GO:0001817 | 0.008037232734484233906413486181 | 2.094893 | 673 | 60 | 12 | 0.01783061 | HERC5,GBP1,ISG15,IRF7,DDX58,UBA7,LPL,DHX58,IL15,UBE2L6,ENSG00000154451,STAT1 |
GO:BP | biological process involved in symbiotic interaction | GO:0044403 | 0.008088540876998565748445813028 | 2.092130 | 545 | 157 | 18 | 0.03302752 | REG3G,CCL5,ISG15,IRF7,MX1,OASL,IFIT5,STAT1,CCL4,SP100,EIF2AK2,CXCR6,OAS3,OAS2,B2M,TRIM14,UBB,PCSK5 |
GO:BP | pyridine-containing compound biosynthetic process | GO:0072525 | 0.008794124705796812005442752991 | 2.055807 | 29 | 145 | 5 | 0.17241379 | IDO1,PARP9,IDO2,PARP16,NAMPT |
GO:BP | nicotinamide nucleotide metabolic process | GO:0046496 | 0.008794124705796812005442752991 | 2.055807 | 29 | 145 | 5 | 0.17241379 | IDO1,PARP9,IDO2,PARP16,NAMPT |
GO:BP | pyridine nucleotide metabolic process | GO:0019362 | 0.008794124705796812005442752991 | 2.055807 | 29 | 145 | 5 | 0.17241379 | IDO1,PARP9,IDO2,PARP16,NAMPT |
GO:BP | positive regulation of immune system process | GO:0002684 | 0.008873472851823728177467209832 | 2.051906 | 915 | 125 | 21 | 0.02295082 | DDX60,GBP1,ENSG00000211892,CCL5,DDX58,CXCL10,PSMB8,PSMB9,PARP9,DHX58,IL15,IGHM,ENSG00000154451,CCL4,NFKBIZ,IL18R1,MUC13,DPP4,ENSG00000243290,DCSTAMP,TNFSF13 |
GO:BP | cytokine production | GO:0001816 | 0.009932246839230432153278194107 | 2.002952 | 720 | 184 | 23 | 0.03194444 | HERC5,GBP1,ISG15,IRF7,DDX58,UBA7,LPL,DHX58,IL15,UBE2L6,ENSG00000154451,STAT1,IL18R1,TLR3,EIF2AK2,IRF1,IFIH1,B2M,PCSK5,IFNG,CD200R1,IL18,ABCD2 |
GO:BP | positive regulation of tyrosine phosphorylation of STAT protein | GO:0042531 | 0.010083997136491633025978664762 | 1.996367 | 63 | 181 | 7 | 0.11111111 | CCL5,PARP14,PARP9,IL15,TNFRSF1A,IFNG,IL18 |
GO:BP | RIG-I signaling pathway | GO:0039529 | 0.011017628128537782644658094000 | 1.957912 | 24 | 84 | 4 | 0.16666667 | DDX60,DDX58,DHX58,BIRC3 |
GO:BP | protein mono-ADP-ribosylation | GO:0140289 | 0.011354509404727358007347604030 | 1.944832 | 12 | 180 | 4 | 0.33333333 | PARP14,PARP9,PARP16,PARP12 |
GO:BP | regulation of multicellular organismal process | GO:0051239 | 0.011804682301509236350134379734 | 1.927946 | 2,263 | 129 | 37 | 0.01634998 | REG3G,HERC5,GBP1,ISG15,IRF7,DDX58,CXCL10,FABP4,UBA7,LPL,FGB,ANGPTL3,DHX58,IL15,UBE2L6,ENSG00000154451,STAT1,TNNI3K,TNNC1,SP100,FGF12,CCN3,NFKBIZ,MAP2K6,IL18R1,TLR3,EIF2AK2,FAP,EFNA1,FASLG,IRF1,KCNA2,IFIH1,DCSTAMP,TNFSF13,OAS2,TNFRSF1A |
GO:BP | detection of virus | GO:0009597 | 0.012574869131926503379448334385 | 1.900497 | 6 | 118 | 3 | 0.50000000 | DDX58,TLR3,IFIH1 |
GO:BP | positive regulation of response to cytokine stimulus | GO:0060760 | 0.014085081794381093187040754344 | 1.851241 | 44 | 48 | 4 | 0.09090909 | DDX58,CASP4,PARP14,PARP9 |
GO:BP | granulocyte migration | GO:0097530 | 0.015738814426588074169011122194 | 1.803028 | 127 | 63 | 6 | 0.04724409 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:BP | proteolysis | GO:0006508 | 0.016257196519430420350582622291 | 1.788954 | 1,453 | 198 | 37 | 0.02546456 | UBD,USP18,ISG15,DDX58,FGB,PSMB8,CASP4,TNFSF10,PSMB9,UBE2L6,CTSS,ECRG4,EGLN3,BIRC3,ZER1,ERAP1,DPP4,FAP,EFNA1,FASLG,USP25,DTX3L,IFIH1,DELE1,ENSG00000198848,PSME2,UBB,PCSK5,FBXL3,NUB1,IFNG,RNF19B,PSME1,SLC11A2,PLGRKT,SERPINF1,CASP7 |
GO:BP | regulation of response to cytokine stimulus | GO:0060759 | 0.017081049186212921009442311515 | 1.767485 | 175 | 163 | 10 | 0.05714286 | USP18,DDX58,CASP4,PARP14,PARP9,STAT1,BIRC3,IFIH1,TNFRSF1A,IFNG |
GO:BP | positive regulation of cytokine production | GO:0001819 | 0.019242515885522521595918377102 | 1.715738 | 361 | 118 | 12 | 0.03324100 | IRF7,DDX58,LPL,DHX58,IL15,ENSG00000154451,STAT1,IL18R1,TLR3,EIF2AK2,IRF1,IFIH1 |
GO:BP | monocyte chemotaxis | GO:0002548 | 0.020504980579209870078516431136 | 1.688141 | 66 | 74 | 5 | 0.07575758 | CCL5,CXCL10,ENSG00000181374,CCL4,CCN3 |
GO:BP | positive regulation of response to biotic stimulus | GO:0002833 | 0.025307661028921766416255323406 | 1.596748 | 223 | 59 | 7 | 0.03139013 | DDX60,CCL5,PSMB8,PSMB9,PARP9,DHX58,ENSG00000154451 |
GO:BP | humoral immune response | GO:0006959 | 0.026724415583798521306446716039 | 1.573092 | 358 | 52 | 8 | 0.02234637 | REG3G,ENSG00000211892,CXCL10,CXCL11,CXCL9,FGB,ENSG00000181374,IGHM |
GO:BP | viral life cycle | GO:0019058 | 0.026858510472143350827911589818 | 1.570918 | 279 | 157 | 12 | 0.04301075 | CCL5,ISG15,MX1,OASL,IFIT5,EIF2AK2,CXCR6,OAS3,OAS2,TRIM14,UBB,PCSK5 |
GO:BP | T cell chemotaxis | GO:0010818 | 0.027158461976962689626846625401 | 1.566095 | 26 | 31 | 3 | 0.11538462 | CCL5,CXCL10,CXCL11 |
GO:BP | extrinsic apoptotic signaling pathway via death domain receptors | GO:0008625 | 0.031769736470525340721327012261 | 1.497986 | 70 | 129 | 6 | 0.08571429 | FGB,TNFSF10,SP100,FASLG,DELE1,TNFRSF1A |
GO:BP | myeloid leukocyte migration | GO:0097529 | 0.032237425441707996676132808034 | 1.491640 | 187 | 100 | 8 | 0.04278075 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4,CCN3,DPP4 |
GO:BP | regulation of tyrosine phosphorylation of STAT protein | GO:0042509 | 0.035343105441357679230574007079 | 1.451695 | 76 | 181 | 7 | 0.09210526 | CCL5,PARP14,PARP9,IL15,TNFRSF1A,IFNG,IL18 |
GO:BP | regulation of viral life cycle | GO:1903900 | 0.036608855892332779757847305291 | 1.436414 | 160 | 155 | 9 | 0.05625000 | CCL5,ISG15,MX1,OASL,IFIT5,EIF2AK2,OAS3,OAS2,TRIM14 |
GO:BP | regulation of leukocyte apoptotic process | GO:2000106 | 0.037976392213871619507603583088 | 1.420486 | 57 | 16 | 3 | 0.05263158 | IDO1,CCL5,IRF7 |
GO:BP | defense response to bacterium | GO:0042742 | 0.038611585882333931962762108014 | 1.413282 | 274 | 35 | 6 | 0.02189781 | REG3G,ENSG00000211892,LYG2,ISG15,ENSG00000213512,FGB |
GO:BP | antigen processing and presentation of peptide antigen via MHC class I | GO:0002474 | 0.040477921918480874730050800281 | 1.392782 | 98 | 197 | 8 | 0.08163265 | TAP1,PSMB8,PSMB9,ERAP1,PSME2,B2M,PSME1,TAPBPL |
GO:BP | positive regulation of calcium ion transport | GO:0051928 | 0.042425557760902447845818841188 | 1.372372 | 90 | 63 | 5 | 0.05555556 | CCL5,CXCL10,CXCL11,CXCL9,CCL4 |
GO:BP | I-kappaB kinase/NF-kappaB signaling | GO:0007249 | 0.042429414043221765073798934509 | 1.372333 | 268 | 171 | 12 | 0.04477612 | UBD,TNFSF10,IFIT5,STAT1,BIRC3,TLR3,FASLG,TNFRSF1A,TRIM14,UBB,OPTN,UNC5CL |
GO:BP | regulation of ribonuclease activity | GO:0060700 | 0.043428409855841322573244411842 | 1.362226 | 8 | 127 | 3 | 0.37500000 | OASL,OAS3,OAS2 |
GO:BP | positive regulation of defense response to virus by host | GO:0002230 | 0.045261247932569206864350519481 | 1.344273 | 28 | 211 | 5 | 0.17857143 | DDX58,PARP9,STAT1,DTX3L,PTPN22 |
GO:BP | tyrosine phosphorylation of STAT protein | GO:0007260 | 0.045584919589489750202382367661 | 1.341179 | 79 | 181 | 7 | 0.08860759 | CCL5,PARP14,PARP9,IL15,TNFRSF1A,IFNG,IL18 |
GO:CC | extracellular space | GO:0005615 | 0.000303302593014462599195490977 | 3.518124 | 3,478 | 164 | 60 | 0.01725129 | REG3G,ENSG00000211892,CCL5,ACTN2,CXCL10,FAM3B,FABP4,SMPDL3A,LPL,CXCL11,COL8A1,CXCL9,FGB,ANGPTL3,PSMB8,TNFSF10,PSMB9,ENSG00000181374,ALDOC,IL15,IGHM,CCL4,CTSS,ECRG4,FGF12,PIGR,TLR3,KRT12,MUC13,ERAP1,DPP4,FAP,IL18BP,FASLG,AOX1,ENSG00000243290,SLC5A1,QDPR,PLS1,OAS3,TNFSF13,SNCG,TNFRSF1A,STOM,ITIH3,SLCO4C1,CRYAB,ENSG00000198848,GNRH1,ALDH1L1,AOC1,ITGA4,NAMPT,PSME2,B2M,UBB,PCSK5,SLC36A2,IFNG,GLIPR2 |
GO:CC | extracellular region | GO:0005576 | 0.000396882735200112743163131102 | 3.401338 | 4,025 | 164 | 66 | 0.01639752 | REG3G,ENSG00000211892,LYG2,CCL5,ISG15,ACTN2,CXCL10,FAM3B,FABP4,SMPDL3A,LPL,CXCL11,COL8A1,CXCL9,FGB,ANGPTL3,PSMB8,TNFSF10,PSMB9,ENSG00000181374,ALDOC,IL15,IGHM,ENSG00000163295,CCL4,CTSS,ECRG4,FGF12,CCN3,PIGR,TLR3,KRT12,MUC13,LAMB3,ERAP1,DPP4,FAP,IL18BP,FASLG,AOX1,ENSG00000243290,SLC5A1,QDPR,PLS1,OAS3,TNFSF13,SNCG,TNFRSF1A,STOM,LIPK,ITIH3,SLCO4C1,CRYAB,ENSG00000198848,GNRH1,ALDH1L1,AOC1,ITGA4,NAMPT,PSME2,B2M,UBB,PCSK5,SLC36A2,IFNG,GLIPR2 |
GO:CC | spermatoproteasome complex | GO:1990111 | 0.021461350957907195102780661955 | 1.668343 | 5 | 43 | 2 | 0.40000000 | PSMB8,PSMB9 |
GO:MF | double-stranded RNA binding | GO:0003725 | 0.000000943246105109492546068883 | 6.025375 | 72 | 127 | 9 | 0.12500000 | DDX60,DDX58,OASL,DHX58,TLR3,EIF2AK2,IFIH1,OAS3,OAS2 |
GO:MF | chemokine receptor binding | GO:0042379 | 0.000002129945551721784189561776 | 5.671631 | 70 | 63 | 7 | 0.10000000 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,STAT1,CCL4 |
GO:MF | identical protein binding | GO:0042802 | 0.000004983028800194959721456267 | 5.302507 | 1,842 | 164 | 43 | 0.02334419 | GBP1,CCL5,ACTN2,DDX58,IFIT3,MX1,AQP4,LPL,TAP1,TNFSF10,THRSP,ENSG00000154451,STAT1,CCL4,PRF1,TNNC1,SP100,MAP2K6,TRIM69,TLR3,PFKFB1,EIF2AK2,MUC13,DPP4,FAP,AOX1,IFIH1,TNFRSF1A,STOM,CRYAB,SLAMF7,HSD11B1,AOC1,NAMPT,KCTD9,NMI,ZDHHC2,PSME2,GRAMD2B,B2M,TRIM14,OPTN,GLIPR2 |
GO:MF | chemokine activity | GO:0008009 | 0.000007035796871417808976290759 | 5.152687 | 48 | 63 | 6 | 0.12500000 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,CCL4 |
GO:MF | signaling receptor binding | GO:0005102 | 0.000022379283058333317131885498 | 4.650154 | 1,438 | 104 | 27 | 0.01877608 | ENSG00000211892,CCL5,ISG15,ACTN2,CXCL10,FAM3B,OASL,LPL,CXCL11,CXCL9,FGB,ANGPTL3,TAP1,TNFSF10,ENSG00000181374,IL15,IGHM,STAT1,CCL4,FGF12,CCN3,ERAP1,DPP4,FAP,IL18BP,EFNA1,FASLG |
GO:MF | CXCR3 chemokine receptor binding | GO:0048248 | 0.000024575255319483706017286151 | 4.609502 | 5 | 34 | 3 | 0.60000000 | CXCL10,CXCL11,CXCL9 |
GO:MF | cytokine activity | GO:0005125 | 0.000094393118517540727432230119 | 4.025060 | 179 | 63 | 8 | 0.04469274 | CCL5,CXCL10,FAM3B,CXCL11,CXCL9,ENSG00000181374,IL15,CCL4 |
GO:MF | receptor regulator activity | GO:0030545 | 0.000362266363824942534948431172 | 3.440972 | 419 | 192 | 18 | 0.04295943 | CCL5,CXCL10,FAM3B,CXCL11,CXCL9,ANGPTL3,ENSG00000181374,IL15,CCL4,FGF12,DPP4,IL18BP,IL17B,GNRH1,NAMPT,IFNG,IL18,WFIKKN2 |
GO:MF | CCR5 chemokine receptor binding | GO:0031730 | 0.000566415266480342258735569683 | 3.246865 | 7 | 63 | 3 | 0.42857143 | CCL5,STAT1,CCL4 |
GO:MF | receptor ligand activity | GO:0048018 | 0.000699621445405716312765376230 | 3.155137 | 373 | 181 | 16 | 0.04289544 | CCL5,CXCL10,FAM3B,CXCL11,CXCL9,ANGPTL3,ENSG00000181374,IL15,CCL4,FGF12,DPP4,IL17B,GNRH1,NAMPT,IFNG,IL18 |
GO:MF | signaling receptor activator activity | GO:0030546 | 0.000831023227956924890637291359 | 3.080387 | 378 | 181 | 16 | 0.04232804 | CCL5,CXCL10,FAM3B,CXCL11,CXCL9,ANGPTL3,ENSG00000181374,IL15,CCL4,FGF12,DPP4,IL17B,GNRH1,NAMPT,IFNG,IL18 |
GO:MF | glycosaminoglycan binding | GO:0005539 | 0.001427061300239580894644308984 | 2.845557 | 153 | 74 | 7 | 0.04575163 | REG3G,CXCL10,LPL,CXCL11,IGHM,FGF12,CCN3 |
GO:MF | protein homodimerization activity | GO:0042803 | 0.001905126882183587073288366653 | 2.720076 | 637 | 217 | 23 | 0.03610675 | GBP1,CCL5,LPL,TAP1,ENSG00000154451,STAT1,TNNC1,SP100,MUC13,DPP4,FAP,AOX1,CRYAB,HSD11B1,AOC1,ZDHHC2,B2M,TRIM14,GLIPR2,ABCD2,TXN,JAML,CALCOCO2 |
GO:MF | CXCR chemokine receptor binding | GO:0045236 | 0.001970652182273487356550800698 | 2.705390 | 18 | 34 | 3 | 0.16666667 | CXCL10,CXCL11,CXCL9 |
GO:MF | carbohydrate derivative binding | GO:0097367 | 0.002428562642885101052064866778 | 2.614651 | 807 | 74 | 14 | 0.01734820 | REG3G,GBP1,CXCL10,ENSG00000213512,MX1,LPL,CXCL11,TAP1,PARP9,IGHM,ENSG00000154451,CTSS,FGF12,CCN3 |
GO:MF | indoleamine 2,3-dioxygenase activity | GO:0033754 | 0.003662862539728325202842418307 | 2.436179 | 2 | 56 | 2 | 1.00000000 | IDO1,IDO2 |
GO:MF | protein ADP-ribosylase activity | GO:1990404 | 0.006636408023937247040169307155 | 2.178067 | 16 | 180 | 4 | 0.25000000 | PARP14,PARP9,PARP16,PARP12 |
GO:MF | cytokine receptor binding | GO:0005126 | 0.007354131266621667314953292305 | 2.133469 | 232 | 63 | 7 | 0.03017241 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,STAT1,CCL4 |
GO:MF | CCR chemokine receptor binding | GO:0048020 | 0.008983577686121122993223586661 | 2.046551 | 47 | 63 | 4 | 0.08510638 | CCL5,ENSG00000181374,STAT1,CCL4 |
GO:MF | tryptophan 2,3-dioxygenase activity | GO:0004833 | 0.010965758143521842776779706696 | 1.959961 | 3 | 56 | 2 | 0.66666667 | IDO1,IDO2 |
GO:MF | interleukin-18 binding | GO:0042007 | 0.012251561650740648221069584167 | 1.911809 | 2 | 102 | 2 | 1.00000000 | IL18R1,IL18BP |
GO:MF | G protein-coupled receptor binding | GO:0001664 | 0.013803995910325189688805380683 | 1.859995 | 256 | 63 | 7 | 0.02734375 | CCL5,CXCL10,CXCL11,CXCL9,ENSG00000181374,STAT1,CCL4 |
GO:MF | protein dimerization activity | GO:0046983 | 0.014113984088935528637964722520 | 1.850350 | 762 | 220 | 24 | 0.03149606 | GBP1,CCL5,LPL,TAP1,ENSG00000154451,STAT1,TNNC1,SP100,MUC13,DPP4,FAP,AOX1,CRYAB,HSD11B1,AOC1,ZDHHC2,B2M,TRIM14,GLIPR2,ABCD2,TXN,JAML,CALCOCO2,UBA3 |
GO:MF | ISG15 transferase activity | GO:0042296 | 0.018126856131210025702138466386 | 1.741678 | 4 | 51 | 2 | 0.50000000 | HERC5,UBE2L6 |
GO:MF | heparin binding | GO:0008201 | 0.026682348594784910389421384025 | 1.573776 | 102 | 74 | 5 | 0.04901961 | CXCL10,LPL,CXCL11,FGF12,CCN3 |
GO:MF | ion binding | GO:0043167 | 0.035077252754158821934638012863 | 1.454974 | 1,765 | 130 | 28 | 0.01586402 | GBP1,ACTN2,DDX58,ENSG00000213512,MX1,FABP4,SMPDL3A,LPL,TAP1,TNFSF10,PARP9,DHX58,IGHM,ENSG00000163295,ENSG00000154451,PRF1,TNNC1,EGLN3,NUAK2,ERAP1,AOX1,QDPR,IFIH1,PCP4,OAS3,SNCG,OAS2,DNASE1L3 |
GO:MF | cytokine binding | GO:0019955 | 0.037929820692372315238394264725 | 1.421019 | 131 | 192 | 8 | 0.06106870 | GBP1,IL18R1,IL18BP,CXCR6,XCR1,TNFRSF1A,ITGA4,WFIKKN2 |
GO:MF | single-stranded RNA binding | GO:0003727 | 0.049318148594688783481476690440 | 1.306993 | 80 | 57 | 4 | 0.05000000 | DDX60,DDX58,DHX58,IFIT5 |